Myricetin
MYC
Background info
Myricetin (MYC) is a flavonoid compound that is found not only in cannabis but also in a variety of other plants, including berries, onions, and certain vegetables. It belongs to the flavonol subclass of flavonoids and is known for its potential health benefits. In cannabis, myricetin is one of several flavonoids present in the plant, contributing to the complex chemical profile of the cannabis plant. Myricetin has gained attention for its antioxidant and anti-inflammatory properties, which make it a subject of interest in medical and therapeutic research. These properties suggest that myricetin may play a role in protecting cells from oxidative damage and reducing inflammation, which are factors associated with various chronic diseases. However, the specific actions and potential therapeutic applications of myricetin in the context of cannabis are still an area of ongoing investigation, and more research is needed to fully understand its effects and potential benefits.
MYC as antioxidant
The article titled “Antioxidant activity of quercetin and myricetin in liposomes” by Michael H. Gordon and Andrea Roedig-Penman, published in the Chemistry and Physics of Lipids in 1998, provides valuable insights into the antioxidant properties of myricetin. The study investigates the antioxidant activity of myricetin in liposomes, which are lipid-based structures that mimic cell membranes. The research findings demonstrate that myricetin exhibits significant antioxidant activity in this model system, effectively protecting liposomes from oxidative damage. This suggests that myricetin has the ability to scavenge free radicals and reduce lipid peroxidation, which are processes associated with oxidative stress and cellular damage. Myricetin’s antioxidant properties are attributed to its chemical structure, which includes multiple hydroxyl groups that can neutralize reactive oxygen species. Additionally, according to “Myricetin suppresses oxidative stress-induced cell damage via both direct and indirect antioxidant action” by Zhi Hong Wang et al., Myricetin indirectly enhances the cellular antioxidant defense systems, such as the activity of superoxide dismutase (SOD) and catalase (CAT). These findings underscore myricetin’s potential as a potent natural antioxidant, which may have applications in protecting cells and tissues from oxidative stress-related diseases and conditions, including cardiovascular disease, neurodegenerative disorders, and cancer. However, further research is needed to explore its effects in vivo and its practical applications in human health.
MYC as anti-inflammatory
The article titled “Myricetin attenuates LPS-induced inflammation in RAW 264.7 macrophages and mouse models” by Wei Hou et al., published in Future Medicinal Chemistry in 2018, provides valuable insights into the anti-inflammatory properties of myricetin. The study demonstrates that myricetin effectively attenuates inflammation induced by lipopolysaccharide (LPS) in both macrophage cell models and mouse models. Myricetin’s ability to reduce the production of pro-inflammatory molecules and cytokines suggests its potential as an anti-inflammatory agent. The article “Myricetin: A comprehensive review on its biological potentials” by Imran et al., explains myricetin’s ability to modulate various inflammatory pathways and signaling molecules, including cytokines and enzymes like cyclooxygenase (COX) and lipoxygenase (LOX), which are central players in the inflammatory response. The findings highlight myricetin’s capacity to modulate the immune response and suppress the inflammatory process, making it a promising candidate for the development of anti-inflammatory therapies. However, while this research underscores the potential benefits of myricetin in managing inflammation, further studies and clinical trials would be necessary to confirm its efficacy and safety for use in human inflammatory conditions.
MYC as anti-tumor
The article titled “Anti-tumor effects and associated molecular mechanisms of myricetin” by Min Jiang et al., published in Biomedicine & Pharmacotherapy in 2019, provides a comprehensive analysis of the anti-tumor properties of myricetin. The study delves into the mechanisms underlying myricetin’s potential as an anticancer agent. Myricetin, a flavonoid found in various fruits and vegetables, is shown to exert anti-tumor effects through several molecular pathways. It is reported to inhibit cancer cell proliferation, induce apoptosis (programmed cell death) in cancer cells, and interfere with tumor angiogenesis and metastasis. These actions are attributed to myricetin’s ability to modulate various cellular signaling pathways, including those related to inflammation and oxidative stress. Additionally, myricetin is noted for its potential to enhance the effectiveness of conventional cancer therapies and mitigate their side effects. While the study provides valuable insights, further research, including clinical trials, is needed to validate myricetin’s efficacy and safety as a potential therapeutic agent in cancer treatment. Nonetheless, these findings highlight the promising potential of myricetin in the fight against cancer and its multifaceted role in suppressing tumor growth.